Answer is: mass of insulin in the bottle is 8500 milligrams or 8.5 grams.
V(insulin) = 425 ml; volume of solution.
d(insulin) = 20.0 mg/ml; density of solution.
m(insulin) = V(insulin) · d(insulin).
m(insulin) = 425 ml · 20 mg/ml.
m(insulin) = 8500 mg.
m(insulin) = 8500 mg ÷ 1000 ml/l.
m(insulin) = 8.5 g.