Which of the following statements is true regarding protein structure determination?
A. Mass spectrometry is the fastest way to determine the three-dimensional structure of a polypeptide or protein, regardless of its size.
B. A protein’s three-dimensional structure can be reliably predicted from its amino acid sequence by computer algorithms that access the vast quantities of structural information archived in public databases.
C. Mass spectrometry can be used to determine the amino acid sequences of a complex mixture of different proteins.
D. Determination of a protein’s structure by X-ray crystallography does not require prior knowledge of its amino acid sequence.
E. Nuclear magnetic resonance can be used to determine the structure of proteins that are too large to crystallize.

Respuesta :

Answer:

The answer is: B. The three-dimensional structure of a protein can be predicted reliably from its amino acid sequence using computer algorithms that access the large amount of structural information stored in public databases.

Explanation:

The prediction of the structure of proteins is the prediction or calculation of the three-dimensional structure of a protein from its amino acid sequence, that is, the prediction of its secondary and tertiary structures from its primary structure.

There are two basic strategies for approaching structure prediction: de novo prediction, in which stochastic methods are often used; and prediction by comparison, in which a library of previously known structures is used.

The secondary structure prediction is a set of bioinformatics techniques whose objective is to predict the local secondary structure of protein and RNA sequences based only on the knowledge of their primary structure of amino acids or nucleotides, respectively.

The answer is: B. The three-dimensional structure of a protein can be predicted reliably from its amino acid sequence using computer algorithms that access the large amount of structural information stored in public databases.

Answer:

C. Mass spectrometry can be used to determine the amino acid sequences of a complex mixture of different proteins.

Explanation:

The answer is C.