A pregnant mother recently had an ultrasound that indicated massive defects in the formation of her unborn baby’s heart. Other oddities were noted in the spinal cord region, the kidneys, and the formation of the facial features. She had an amniocentesis to examine the baby’s karyology, and it was noted that there was a deletion of a small piece of one chromosome. The doctors advised her that she would likely miscarry. The devastated parents consult you as a genetic advisor on the likelihood that a future pregnancy would end similarly. What advice do you give this unfortunate couple?