Answer: The change in one or more amino acids in a protein will result in a non functional protein or a protein whose function has been altered.
Explanation: Example is a protein called haemoglobin. Haemoglobin is a tetrameric protein found in the red blood cells that is responsible for the transport of oxygen throughout the body. In the normal haemoglobin (A), there is a glutamate residue in the 6th position of the two beta chains but in the mutated haemoglobin (S), valine replaces glutamate in the 6th position of the two beta chain. This gives the red blood cells a sickle shape that results in sickle cell disease. This sickle red blood cells have low affinity for oxygen thereby leading to abnormal circulation of oxygen in the body.
