Substituion mutation is responsible for small changes in a trait.
Explanation:
This kind of mutation merely changes the type of nucleotide in the DNA sequence. The mutation does not cause a frameshift as would a deletion of addition mutation.
A substitution mutation would at worst change an amino acid in the translated protein. This would likely have a slight effect on how the protein folds into an active protein. On the other hand, mutations that cause frameshifts have the biggest effect on the proteins. They change all the amino acids of a protein downstream of the point of mutation.
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