Cushing syndrome is caused by an increase in the synthesis of cortisol in the adrenal gland. Which of the following compounds is directly required as a substrate for the synthesis of this hormone?
A) cholesterol
B) glucose
C) free fatty acids
D) amino acids

Cushing Syndrome occurs as a result of exposure of the body to elevated levels of cortisol hormone (stress hormone) for a long time. The elevated level of cortisol which is a steroid hormone, results from increased synthesis of cortisol in the adrenal glands. Cortisol is synthesized from a substrate called, cholesterol. Cortisol synthesis occurs in the zona fasciculata of the adrenal cortex and controlled or regulated by the hypothalamus-pituitary-adrenal axis or HPA axis.

Cholesterol, which is an important substrate in cortisol synthesis, is a lipid usually found in cells and plays an important function in hormone synthesis, food digestion and synthesis of Vitamin D.

Cushing syndrome is caused by an increase in the synthesis of cortisol in the adrenal gland. Which of the following compounds is directly required as a substrate for the synthesis of this hormone? A) cholesterol B) glucose C) free fatty acids D) amino acids

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Cushing syndrome is caused by an increase in the synthesis of cortisol in the adrenal gland. Which of the following compounds is directly required as a substrate for the synthesis of this hormone?
A) cholesterol
B) glucose
C) free fatty acids
D) amino acids