Neural control of GFR is mediated by Sympathetic neurons that innervate alpha receptors on vascular smooth muscle causing Vasoconstriction.
How is GFR regulated?
- The sympathetic division of the nervous system regulates the GFR or Glomerular Filtration Rate.
- GFR is the sum total of filtration rates of all the working nephrons in the kidney.
- Sympathetic division comes into action when the mean arterial pressure is very low (below 80mmHg).
- In response to low blood pressure, the medulla releases norepinephrine through sympathetic nerves.
- Norepinephrine leads to activation of alpha receptors on arteries which cause vasoconstriction.
- Alpha receptors are more abundant on afferent arterioles.
- This leads to vasoconstriction (narrowing) of arteries supplying to the glomerulus.
- This decreases blood flow to glomerulus, leading to decrease in GFR.
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