Destruction of lymphocytes with self-specificity is called clonal deletion.
Clonal deletion is the removal through apoptosis of B cells and T cells that have expressed receptors for self before developing into fully immunocompetent lymphocytes. This prevents recognition and destruction of self host cells, making it a type of negative selection or central tolerance.
Clonal selection is antigenic-specific selection of a lymphocyte that activates it to produce clones of effector cells dedicated to eliminating the antigen that provoked the initial immune response. Clonal selection is the theory that specific antigen receptors exist on lymphocytes before they are presented with an antigen due to random mutations during initial maturation and proliferation.
Hence, the correct option is A
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