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Which body systems are directly responsible for regulating these nodes and protecting the body from harmful materials in tissue fluid?

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The body systems are directly responsible for regulating these nodes and protecting the body from harmful materials in tissue fluid are the immune and lymphatic systems. Lymphatic is a network of tissues and organs that help rid the body of toxins, waste, and other unwanted materials. The immune system on the other hand is the system that prevents the invasion of pathogens causing diseases to the body. 
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The lymphatic system is a collection of tissues, veins, and organs that work together to restore lymph, a colourless, watery fluid, to your circulatory system.

The system that regulates the nodes and protect the body from harmful materials is the Lymphatic system.

The Lymphatic system

  • The lymphatic system is an organ system of all vertebrates which is a part of immune system and circulatory system.

  • It is made up of big network of lymphatic veins, lymph nodes, lymphatic or lymphoid organs, and lymphoid tissues.

  • The vessels carry the lymph fluid. This fluid is white and transparent.

  • This system maintain the fluid of the body and also protects the body from harmful toxins and invaders.

  • It helps in absorption and transfer of fatty acids and fats.

  • Plays a major role in our immune system as it transfer white blood cells from the bones and to the bones.

Thus, the lymphatic system protects the body and remove harmful material from the fluids.

Learn more about, lymphatic system, here:

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